GENETIC ASSOCIATION OF KCNJ11 POLYMORPHISM AND TYPE 2 DIABETES SUSCEPTIBILITY: A CASE-CONTROL APPROACH
DOI:
https://doi.org/10.48165/abr.2025.27.01.1Keywords:
Antidiabetic drugs, Genetic variation, KCNJ11, polymorphism, type 2 diabetes mellitusAbstract
Diabetes is globally one of the leading non-communicable diseases that pose significant public health challenges. The Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) gene polymorphism has been implicated in beta-cell dysfunction and altered insulin secretion through potassium-gated channels, potentially influencing type 2 diabetes mellitus (T2DM) susceptibility. Genotyping was performed using restriction fragment length polymorphism, with verification through Sanger Sequencing. The association between KCNJ11 genotypes and T2DM risk was evaluated using odds ratios and confidence intervals. Biochemical and clinical variables were compared between patients and controls using Student’s t-test and Chi-square (χ²) tests. Statistical analysis was conducted using SPSS software. The frequency distribution of KCNJ11 (rs5210) SNP (A/G) differed significantly between the control group and T2DM patients (X² = 31.7). The dominant genetic model (p value <0.00; OR = 4.41) showed its strong association with T2DM. Drug response analysis highlighted those patients with the GG genotype responded better to metformin + sulfonylurea (M + S) compared to lantus + gliptin (L + G), indicating genotype-specific therapeutic efficacy. This study confirms that the rs5210 genetic variant of KCNJ11 gene significantly increases susceptibility to T2DM. Furthermore, the GG genotype may influence the effectiveness of antidiabetic therapies, providing a potential basis for personalized treatment strategies. These findings underscore the importance of genetic screening in diabetes management.Downloads
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