Exploring Marsdenia Cundurango:  Its History, Phytochemistry and  Anti-cancerous Potential

Anita S. Patil; Chetna Bainiwal

doi:10.48165/ahr.2025.10.1.10

Authors

Anita S. Patil Dean, Head of Department, Department of Repertory Bharati Vidyapeeth (Deemed to Be University) Homoeopathic Medical College, Dept. Of Post Graduate & Research Centre, Pune-Satara Road, Katraj, Dhankawadi, Pune, India - 411043.
Chetna Bainiwal P.G. Scholar, Department of Repertory

DOI:

https://doi.org/10.48165/ahr.2025.10.1.10

Keywords:

cancer, condurango, condurangogenin, cundurango, glycoside, in-vitro, in-vivo

Abstract

Background & Objectives Marsdenia cundurango, a vine native to South America, is a traditionally used therapeutic plant to treat various ailments, particularly in treating gastric disorders and cancer. The objective of this study is to summarize the origin, history, phytochemistry and ethnopharmacology along with significant emphasis given on the anti-cancer properties of Marsdenia cundurango. Methods A comprehensive literature search was conducted to inquire into the historical use, phytochemistry, and pharmacological properties of Marsdenia cundurango. The major phytoconstituents, particularly condurangogenins and cundurango glycosides, were surveyed for their therapeutic potential. Results Various studies have highlighted the anti-cancerous potential of Marsdenia cundurango. In-vitro studies using various cancer cell lines showed that cundurango glycosides (CGA) and condurangogenins (ConA) induce DNA damage, apoptosis, and cell cycle arrest. Various homeopathic potencies of the plant also demonstrated epigenetic modulation, apoptotic and cytotoxic effects in cancer cells. In addition to this, some in-vivo experiments also indicated the anti-cancerous activity of condurango extracts and potencies in animal models. Conclusions Pre-clinical researches support significant anti cancerous potential of Marsdenia cundurango. It has been scrutinized that there is more scope to explore the therapeutic potential of Marsdenia cundurango. Therefore, more studies should be carried out to validate the given literature and to expand its therapeutic usage. Future research should focus on optimizing treatment dosages and exploring the plant’s full therapeutic potential in oncology.

References

1. https://www.luminescents.net/shop/herbal/ traditional-herbs/western-herbal/products beginning-with-c/condurango-bark/

2. https://pcimh.gov.in/WriteReadData/RTF1984/old volume II.pdf

3. UMEHARA, Kaoru, et al. "Studies on differentiation inducers. IV. Pregnane derivatives from Condurango cortex." Chemical and pharmaceutical bulletin 42.3

(1994): 611-616.

4. HAYASHI, KOJI, and HIROSHI MITSUHASHI. "Components of Cortex Condurango." Chemical and Pharmaceutical Bulletin16.12 (1968): 2522-2524.

5. Sikdar, Sourav, et al. "Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo." Environmental Toxicology and Pharmacology 37.1 (2014): 300-

314.

6. Mitsuhashi, Hiroshi, et al. "Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions." U.S. Patent No. 4,452,786. 5 Jun. 1984.

7. Takase M, Terada S, Yamamoto H, Narita T, Kimura M, Hayashi K, Mitsuhashi H (1982) Studies on the constituents of Asclepiadaceae plants. XLIX. Con8rmation of the structures of antitumor

active glycosides in condurango cortex. Chemical transformation of the aglycone moiety. Chem Pharm Bull 30:2429–2432

8. Berger, S., P. Junior, and L. Kopanski. "Structural revision of pregnane ester glycosides from condurango cortex and new compounds." Phytochemistry 27.5 (1988): 1451-1458.

9. Che, C-T., et al. "Traditional medicine." Pharma cognosy. Academic Press, 2024. 11-28.

10. Pfützner, Wolfgang, et al. "Anaphylactic reaction elicited by condurango bark in a patient allergic to natural rubber latex." Journal of allergy and clinical immunology 101.2 (1998): 281-282.

11. Sikdar, Sourav, et al. "Ethanolic extract of Condurango (Marsdenia condurango) used in traditional systems of medicine including homeopathy against cancer can induce DNA damage and apoptosis in non small lung cancer cells, A549 and H522, in vitro." CellMed 3.1 (2013): 9-1

12. Bishayee, Kausik, et al. "Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells." Molecular and cellular biochemistry382 (2013): 173-183.

13. Sikdar, Sourav, Avinaba Mukherjee, and Anisur Rahman Khuda-Bukhsh. "Anti-lung cancer potential of pure esteric-glycoside condurangogenin A against nonsmall-cell lung cancer cells in vitro via p21/p53 mediated cell cycle modulation and DNA damage

induced apoptosis." Pharmacognosy Magazine 11.

Suppl 1 (2015): S73.

14. Bishayee, Kausik, et al. "Condurango (Gonolobus condurango) extract activates fas receptor and depolarizes mitochondrial membrane potential to induce ROS-dependent apoptosis in cancer cells in vitro: CE-treatment on HeLa: a ROS-dependent mechanism." Journal of pharmacopuncture18.3 (2015): 32.

15. Maqbool, Tahir, et al. "Synergistic Effect of Barbadensis miller and Marsdenia Condurango Extracts Induces Apoptosis Promotes Oxidative Stress by Limiting Proliferation of Cervical Cancer and Liver Cancer Cells." Asian Pacific Journal of Cancer Prevention: APJCP 22.3 (2021): 843.

16. Bishayee, Kausik, Sourav Sikdar, and Anisur Rahman Khuda-Bukhsh. "Evidence of an epigenetic modification in cell-cycle arrest caused by the use of ultra-highly-diluted Gonolobus condurango extract." Journal of pharmacopuncture 16.4 (2013):7.

17. Khuda-Bukhsh, Anisur Rahman, Santu Kumar Saha, and Sourav Roy. "Evidence in support of gene regulatory hypothesis: Gene expression profiling manifests homeopathy effect as more than placebo." International Journal of High Dilution Research-ISSN 1982-6206 12.45 (2013): 162-167.

18. Sikdar, Sourav, et al. "Post-cancer treatment with condurango 30C shows amelioration of Benzo [a] pyrene-induced lung cancer in rats through the molecular pathway of Caspa-se-3-

mediated apoptosis induction:-anti-lung cancer potential of Condurango 30C in rats." Journal of pharmacopuncture 16.3 (2013): 11.

19. Khuda-Bukhsh, Anisur R., and Sourav Sikdar. "Condurango 30C induces epigenetic modification of lung cancer-specific tumour suppressor genes via demethylation." Forschende Komplementärmedizin/ Research in Complementary Medicine22.3 (2015): 172-179.

20. Saha, Santu Kumar, Sourav Roy, and Anisur Rahman Khuda-Bukhsh. "Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro." Journal of integrative medicine 13.6 (2015): 400-411

21. Sikdar, Sourav, Santu Kumar Saha, and Anisur Rahman Khuda-Bukhsh. "Relative apoptosis inducing potential of homeopa-thic Condurango 6C and 30C in H460 lung cancer cells in vitro:- Apoptosis-induction by homeopathic Condurango in H460 cells." Journal of pharmacopuncture 17.1 (2014): 59.