A Hybrid Cnn-Lstm-Based Rnn Model for Classification of Schizophrenia

Authors

  • Teyei Ruth Mangai Department, of Computer Engineering, Near East University, North Cyprus, Mersin-10, Turkey
  • Basil B Duwa Operational Research Centre in Healthcare, Near East University, Nicosia, TRNC, Mersin 10, Turkey
  • Huzaifa Umar Operational Research Centre in Healthcare, Near East University, Nicosia, TRNC, Mersin 10, Turkey
  • Dilber Uzun Ozsahin Department of Medical Diagnostic Imaging, College of Health Science, University of Sharjah, Sharjah, UAE

DOI:

https://doi.org/10.48165/gjs.2025.2108

Keywords:

Schizophrenia, Convolutional, Neural Network, Recurrent Neural, Network, Long Short-Term, Memory and Electroencephalogram

Abstract

Schizophrenia is a mental health condition that affects the behavior and thought  process of a person. With proper treatment, such as medication and therapy, many  people with this medical condition are able to manage their symptoms and live  meaningful lives. Thus, there is a need for early diagnosis of schizophrenia. However,  due to the wide range of symptoms displayed by different schizophrenic patients,  accurately identifying schizophrenia can proof challenging. Different conventional  methods to try to classify schizophrenia are applied in many instances. Nevertheless,  all aspects of the condition could not be sufficiently addressed by any of the  conventional classification techniques. Researchers are currently testing the  application of deep learning approaches for improved schizophrenia categorization. In  this study, we present a novel hybrid RNN model that uses both CNN and LSTM  technology for use in the classification of schizophrenia. The twelve layered model  was developed using a total of 28 samples as input data. The dataset consisted of EEG  signal recordings from 14 healthy controls and 14 schizophrenic patients. After  training and testing, an accuracy of 79.35% was recorded by the model. This model  has the potential to enable early detection of schizophrenia thereby leading to more  optimized treatment and management methods. The study describes a new twelve layered CNN-LSTM hybrid framework for identifying schizophrenia employing EEG  signals. Trained on data from 14 patients and 14 healthy controls, the framework  obtained 79.35% accuracy, highlighting deep learning's promise for early success  in schizophrenia detection. 

 

Author Biographies

  • Basil B Duwa, Operational Research Centre in Healthcare, Near East University, Nicosia, TRNC, Mersin 10, Turkey

    Department of Biomedical Engineering Near East University, Nicosia, TRNC, Mersin 10, Turkey

  • Huzaifa Umar, Operational Research Centre in Healthcare, Near East University, Nicosia, TRNC, Mersin 10, Turkey

    Department of Biomedical Engineering Near East University, Nicosia, TRNC, Mersin 10, Turkey

  • Dilber Uzun Ozsahin, Department of Medical Diagnostic Imaging, College of Health Science, University of Sharjah, Sharjah, UAE

    Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE 

     

References

Choomung, P., He, Y., Matsunaga, M., Sakuma, K., Kishi, T., Li, Y., Tanihara, S., Iwata, N., & Ota, A. (2025). Estimating the prevalence of schizophrenia in the general population of Japan using an artificial neural network-based schizophrenia classifier: Web-based cross-sectional survey. JMIR Formative Research, 9(1), e66330.

Duwa, B. B., Onakpojeruo, E. P., Uzun, B., Hussain, A. J., Ozsahin, I., David, L. R., & Ozsahin, D. U. (2024). Ensemble predictive modeling for dementia diagnosis. Proceedings - International Conference on Developments in E-Systems Engineering (DeSE), 352–357.

Duwa, B. B., Usanase, N., & Uzun, B. (2025). Enhanced drug classification for cancers of the liver with multi-criteria decision-making method-PROMETHEE. Global Journal of Sciences, 2(1), 88–98.

Emegano, D. I., Duwa, B. B., Usman, A. G., Ahmad, H., Ozsahin, D. U., & Askar, S. (2025). A comparative study on TB incidence and HIV-TB coinfection using machine learning models on WHO global TB dataset. Scientific Reports, 15(1), 1–14.

Fu, J., Yang, S., He, F., He, L., Li, Y., Zhang, J., & Xiong, X. (2021). Sch-net: A deep learning architecture for automatic detection of schizophrenia. BioMedical Engineering Online, 20(1), 1–21.

Gan, A., Gong, A., Ding, P., Yuan, X., Chen, M., Fu, Y., & Cheng, Y. (2023). Computer-aided diagnosis of schizophrenia based on node2vec and Transformer. Journal of Neuroscience Methods, 389, 109824.

Govil, P., & Kantrowitz, J. T. (2025). Negative symptoms in schizophrenia: An update on research assessment and the current and upcoming treatment landscape. CNS Drugs, 39(3), 243–262.

Huang, Z., Yang, Y., Ma, Y., Dong, Q., Su, J., Shi, H., Zhang, S., & Hu, L. (2025). EEG detection and recognition model for epilepsy based on dual attention mechanism. Scientific Reports, 15(1), 1–16.

Hwang, H. H., Choi, K. M., Kim, S., & Lee, S. H. (2025). Machine learning-based differentiation of schizophrenia and bipolar disorder using multiscale fuzzy entropy and relative power from resting-state EEG. Translational Psychiatry, 15(1), 1–8.

Ko, D.-W., Yang, J.-J., Villalba, J. G., Cicirello, V. A., Papakostas, G. A., & Ko, D.-W. (2022). EEG-based schizophrenia diagnosis through time series image conversion and deep learning. Electronics, 11(14), 2265.

Latha, M., & Kavitha, G. (2019). Detection of schizophrenia in brain MR images based on segmented ventricle region and deep belief networks. Neural Computing and Applications, 31(9), 5195–5206.

Naira, C. A. T., & Del Alamo, C. J. L. (2019). Classification of people who suffer schizophrenia and healthy people by EEG signals using deep learning. International Journal of Advanced Computer Science and Applications, 10(10), 511–516.

Oh, K., Kim, W., Shen, G., Piao, Y., Kang, N. I., Oh, I. S., & Chung, Y. C. (2019). Classification of schizophrenia and normal controls using 3D convolutional neural network and outcome visualization. Schizophrenia Research, 212, 186–195.

Oh, S. L., Vicnesh, J., Ciaccio, E. J., Yuvaraj, R., & Acharya, U. R. (2019). Deep convolutional neural network model for automated diagnosis of schizophrenia using EEG signals. Applied Sciences, 9(14), 2870.

Olejarczyk, E., & Jernajczyk, W. (2017). EEG in schizophrenia. Clinical Neurophysiology Practice, 2, 94–98.

Ozsahin, D. U., Onakpojeruo, E. P., Duwa, B. B., Uzun, B., Zira, Y. F., & Ozsahin, I. (2024). Implementation of artificial intelligence models for enhanced cardiovascular disease prediction and risk assessments. Advances in Science and Engineering Technology International Conferences (ASET).

Qiu, Y., Lin, Q. H., Kuang, L. D., Zhao, W. D., Gong, X. F., Cong, F., & Calhoun, V. D. (2019). Classification of schizophrenia patients and healthy controls using ICA of complex-valued fMRI data and convolutional neural networks. In Lecture Notes in Computer Science (Vol. 11555, pp. 540–547). Springer.

Shoeibi, A., Sadeghi, D., Moridian, P., Ghassemi, N., Heras, J., Alizadehsani, R., Khadem, A., Kong, Y., Nahavandi, S., Zhang, Y. D., & Gorriz, J. M. (2021). Automatic diagnosis of schizophrenia in EEG signals using CNN-LSTM models. Frontiers in Neuroinformatics, 15, 777977.

Tavakoli, H., Rostami, R., Shalbaf, R., & Nazem-Zadeh, M. R. (2025). Diagnosis of schizophrenia and its subtypes using MRI and machine learning. Brain and Behavior, 15(1), e70219.

Usman, A. G., Almousa, M., Daud, H., Duwa, B. B., Suleiman, A. A., Ishaq, A. I., & Abba, S. I. (2025). Second-order based ensemble machine learning technique for modelling river water biological oxygen demand (BOD): Insights into improved learning. Journal of Radiation Research and Applied Sciences, 18(1), 100–110.*

Uzun Ozsahin, D., Duwa, B. B., Ozsahin, I., & Uzun, B. (2024). Quantitative forecasting of malaria parasite using machine learning models: MLR, ANN, ANFIS and random forest. Diagnostics, 14(4), 385.

Uzun Ozsahin, D., Mustapha, M. T., Duwa, B. B., & Ozsahin, I. (2022). Evaluating the performance of deep learning frameworks for malaria parasite detection using microscopic images of peripheral blood smears. Diagnostics, 12(11), 2702.

Uzun Ozsahin, D., Mustapha, M. T., Uzun, B., Duwa, B., & Ozsahin, I. (2023). Computer-aided detection and classification of monkeypox and chickenpox lesion in human subjects using deep learning framework. Diagnostics, 13(2), 292.

van Eck, N. J., & Waltman, L. (2010). Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 84(2), 523–538.

Wang, J., Wang, J., Wang, S., Gu, Y., Liang, K., Li, Y., Zhang, Z., Li, Y., Wang, X., Guo, H., & Zhou, J. (2025). Efficacy of identifying treatment-resistant and non-treatment-resistant schizophrenia using niacin skin flushing response combined with clinical feature. Schizophrenia, 11(1), 1–7.

Wang, S., Zhang, Y., Lv, L., Wu, R., Fan, X., Zhao, J., & Guo, W. (2018). Abnormal regional homogeneity as a potential imaging biomarker for adolescent-onset schizophrenia: A resting-state MRI study and support vector machine analysis. Schizophrenia Research, 192, 179–184.

Zheng, J., Wei, X., Wang, J., Lin, H., Pan, H., & Shi, Y. (2021). Diagnosis of schizophrenia based on deep learning using fMRI. Computational and Mathematical Methods in Medicine, 2021, 8437260.

Published

2025-08-23

How to Cite

A Hybrid Cnn-Lstm-Based Rnn Model for Classification of Schizophrenia. (2025). Global Journal of Sciences, 2(1), 88-98. https://doi.org/10.48165/gjs.2025.2108