Developing Topical Gel Formulation of Erandakarkati (Carica papaya Linn.) Latex for Managing Indralupta: A Preliminary Study

Abstract

Introduction: Indralupta, a tridosha-raktaja vyadhi, is marked by patchy hair loss caused by blocked hair follicles  due to aggravated Rakta and Kapha doshas. This blockage disrupts nutrient flow to the follicles, resulting in hair fall  and bald patches. Ayurveda recommends dietary changes, oral medications, and Panchakarma therapies for restoring  dosha balance. Carica papaya (Erandakarkati) is known for its medicinal properties, especially in its latex, which  contains enzymes like papain and chymopapain with anti-inflammatory and antioxidant effects. Methods: This pilot study aimed to evaluate the efficacy of a topical C. papaya latex gel for treating Indralupta.  Thirteen participants aged 20–60 years were selected from the outpatient department of Dravyaguna at Vaidyaratnam  Ayurveda College. A pre-post interventional design was used, assessing subjective and objective parameters at  baseline, and on the 7th, 14th, 21st, and 28th days. The gel was prepared using Carbopol 934 and triethanolamine and  applied daily for 10 min over 28 days. Safety was ensured through a patch test on healthy volunteers. Results: By the end of the 28-day treatment, nine participants showed no hair fall, and eleven exhibited hair growth  in previously bald areas. However, the bald patch size did not significantly change. No participants reported itching,  and the gel was confirmed safe by the patch test. Demographic analysis showed that most participants were male,  married, educated, and middle-class, with a preference for non-vegetarian diets and spicy foods. The onset of  Indralupta was mostly sudden. Discussion: The C. papaya latex gel showed promise in reducing hair fall and promoting hair regrowth in Indralupta patients over a 28-day period. However, the lack of significant change in bald patch size suggests the need for longer  treatment or additional interventions. The small sample size and short treatment duration limit the generalizability  of the results. Conclusion: C. papaya latex gel may be effective in treating Indralupta, but further research with larger sample sizes  and longer treatment durations is needed to validate these findings.