Comparative Histological Evaluation of the Nictitating Gland Between Cat (Felis Catus) and Rabbits (Oryctolagus Cuniculus)

Authors

  • Walaa F Obead niversity of Kerbala, College of Veterinary Medicine, Department of Veterinary Anatomy and Histology, Karbala-Iraq.
  • Muhaned Sachit Auied Middle Technical University, Kut Technical Institute, Nursing Department, Wasit, Iraq.
  • Hayder Abdullah Kadhim Middle Technical University, Kut Technical Institute, Medical Laboratory Technologies Department, Wasit, Iraq

DOI:

https://doi.org/10.48165/ijapm.2025.41.3.1

Keywords:

Comparative investigation, Nictitating, cats &Rabbits

Abstract

This study focuses on the third eyelid gland morphology and histological examination  in Cats (Felis catus) and Rabbits. From adult rabbits and cats, ten nictitating  membranes were removed and sections examined under a light microscope, and a  macroscope. The entire length of a pigmented long, thin, curved structure resembling  the eyeball was the dorsal and ventral wings of cartilage — that was only complete  in the illustration. Sinus of the ventral wing was less than dorsal wing. There were  lymphoid nodules at the bottom of the refractive outside, and the cartilage had two  surfaces: the corneal and palmebral. The nictitating gland had an oval shape and  seemed to be a [complex acinar gland. The cartilage had isogenous chondrocyte  clusters which were diagnosable under a microscope. Further, these results offer  relevant reference data in supporting future anatomy studies and treatment about  feline third eyelid diseases and aging signs in ocular diseases. Rabbit Nictitating gland  Gland is embedded into the conjunctiva and lateral eyelid . It is called semi-circular  and smooth in form. From this intricate structure, rich in essential lubrication and  protection of the eyes serious and mucous secretions are emitted by a complicated  gland. By histology the gland is made up of acinar cells that are cuboidal or column in  appearance responsible for fluid secretion, Ductal cells displaying stratified cuboidal  or columnar epithelium and help in the transport of secretion, and Myoepithelial  cells as the antagonist in expulsion of glandular contents triggered by contraction.  The connective stroma of this gland, which keeps it from being squishy and gives it  shape, consists of collagen, fibroblasts and elastic fibers. Each of these traits clearly  points to the gland possing a unique function with respect to tear secretion and eye  health in rabbits. 

 

References

Dartt DA. Neural regulation of lacrimal gland secretory processes: Relevance in dry eye diseases. Prog Retin Eye Res. 2009;28(3):155–77. doi:10.1016/j.preteyeres.2009.04.003

Ocran T, Grujicic D. Lacrimal drainage system obstruction. Semin Ophthalmol. 2023;25(3):98–103. doi:10.3109/08820538.2010.488577

Mooney MP, Siegel MI, Opperman LA. Animal models of craniosynostosis: experimental, congenital, and transgenic. In: Mooney MP, Siegel MI, editors. Understanding Craniofacial Anomalies: The Etiopathogenesis of Craniosynostosis and Facial Clefting. New York: John Wiley & Sons; 2011. p. 251–72. doi:10.1155/2011/623186

Mooney MP, Siegel MI. Animal models for bone tissue engineering of critical sized defects (CSDs), bone pathologies, and orthopedic disease states. In: Hollinger JO, Einhorn TA, Doll BA, Sfeir C, editors. Fundamentals of Bone Tissue Engineering. Boca Raton: CRC Press; 2005. p. 217–44.

Frame NJ, Burkat CN. Identifying an appropriate animal model for the nasolacrimal drainage system. Ophthalmic Plast Reconstr Surg. 2009;25(5):354–60. doi:10.1097/IOP.0b013e3181b30358

Hillenius WJ, Rehorek SJ. From the eye to the nose: ancient orbital to vomeronasal communication in tetrapods? In: Mason RT, LeMaster MP, Müller-Schwarze D, editors. Chemical Signals in Vertebrates X. New York: Springer; 2005. p. 228–41.

Burling K, Murphy CJ, Da Silva Curiel J, Koblik P, Bellhorn RW. Anatomy of the rabbit nasolacrimal duct and its clinical implications. Prog Vet Comp Ophthalmol. 1991;1(1):33–40.

Thiessen D. The function of the Harderian gland in the Mongolian gerbil, Meriones unguiculatus. In: Webb SM, Hoffman RA, Puig-Domingo ML, Reiter RJ, editors. Harderian Gland: Porphyrin Metabolism, Behavioral and Endocrine Effects. Berlin: Springer; 1992. p. 127–40.

Rehorek SJ, Hillenius WJ, Quan W, Halpern M. Passage of the Harderian gland secretions to the vomeronasal organ of the snake, Thamnophis sirtalis. Can J Zool. 2000;78(7):1284–8.

Hillenius WJ, Watrobski LK, Rehorek SJ. Passage of tear duct fluids through the nasal cavity of frogs. J Herpetol. 2001;35(4):701–4.

Janssens G, Simoens P, Muylle S, Lauwers H. Bilateral prolapse of the deep gland of the third eyelid in a rabbit: diagnosis and treatment. Lab Anim Sci. 1999;49(1):105–9.

Kittel R. Vergleichend-anatomische Untersuchungen über die Orbitaldrüse der Rodentia. Wiss Z Univ Halle. 1962;4:401–28.

Kühnel W. Morphology of the Harderian gland in the rabbit. In: Webb SM, Hoffman RA, Puig-Domingo ML, Reiter RJ, editors. Harderian Gland: Porphyrin Metabolism, Behavioral and Endocrine Effects. Berlin: Springer; 1992. p. 109–26.

Cooney KA, Chappell JR, Callan RJ, Connally BA. Veterinary Euthanasia Techniques: A Practical Guide. Hoboken: John Wiley & Sons; 2012.

Johnston SA, Tobias KM. Veterinary Surgery: Small Animal Expert Consult. St. Louis: Elsevier Health Sciences; 2017.

Bacha WJ Jr, Bacha LM. Color Atlas of Veterinary Histology. Hoboken: John Wiley & Sons; 2012.

Knop E, Knop N. Anatomy and immunology of the ocular surface. Chem Immunol Allergy. 2007;92:36–49.

Wu F, Zhao Y, Zhang H. Ocular autonomic nervous system: an update from anatomy to physiological functions. Vision. 2022;6(1):6. doi:10.3390/vision6010006

Nebbioso M, Del Regno P, Gharbiya M, Sacchetti M, Plateroti R, Lambiase A. Analysis of the pathogenic factors and management of dry eye in ocular surface disorders. Int J Mol Sci. 2017;18(8):1764. doi:10.3390/ijms18081764

Dartt DA, Hodges RR, Zoukhri D. Tears and their secretion. Adv Organ Biol. 2005;10:21–82. doi:10.1016/S1569-2590(05)10002-0

Dartt DA, Willcox MDP. Complexity of the tear film: importance in homeostasis and dysfunction during disease. Exp Eye Res. 2013;117:1–11. doi:10.1016/j.exer.2013.10.008

Cher I. A new look at lubrication of the ocular surface: fluid mechanics behind the blinking eyelids. Ocul Surf. 2008;6(2):79–86. doi:10.1016/S1542-0124(12)70271-9

Asiedu K, Markoulli M, Bonini S, Bron AJ, Dogru M, Kwai N, et al. Tear film and ocular surface neuropeptides: characteristics, synthesis, signaling and implications for ocular surface and systemic diseases. Exp Eye Res. 2022;218:108973. doi:10.1016/j.exer.2022.108973

Published

2025-10-24

How to Cite

Comparative Histological Evaluation of the Nictitating Gland Between Cat (Felis Catus) and Rabbits (Oryctolagus Cuniculus) . (2025). Indian Journal of Animal Production and Management, 41(3), 1-5. https://doi.org/10.48165/ijapm.2025.41.3.1