Dietary Prebiotics in Augmenting the Antioxidant Enzymes and Thyroid Hor-mones in SVVU T17 Crossbred Pigs
DOI:
https://doi.org/10.48165/ijapm.2025.41.3.4Keywords:
Antioxidant enzymes, Mannan-oligosaccharide, MDA, SVVU T17 pigAbstract
The present study was conducted to investigate the effect of supplementation of prebiotics mannan-oligosaccharide (MOS) on antioxidant and thyroid status in SVVU T17 crossbred pigs. Twenty-four SVVU T17 crossbred male grower pigs above 2 months of age were randomly divided into four groups with six piglets in each group i.e., P0, P1, P2 and P3 groups. The experiment was conducted for 45 days and at the end of experiment blood samples were collected for estimation of antioxidants and thyroid levels. There was a significant increase (P<0.05) in Catalase, SOD and GSH Px enzymes level with raise in MOS concentration in basal diet, whereas MDA levels were significantly (P<0.05) decreased exclusively in P2 and P3. Triiodothyronine levels were not influenced by MOS inclusion in grower diets but Thyroxin hormone levels were significantly (P<0.05) decreased in all groups irrespective of MOS inclusion, whereas TSH hormone levels were raised in P3 group but P1 and P2 groups were in same range with control groups. In conclusion, MOS had a positive influence on antioxidant enzyme (Catalase, SOD and GSH-Px) levels by reducing oxidative stress (MDA levels) significantly (P<0.05), whereas a significant decrease in T4 hormone and increase in TSH levels in SVVU T17 crossbred pigs.References
20th Livestock census (2019). Department of Animal Husbandry, Dairying and Fisheries, Ministry of Agriculture, Government of India, New Delhi.
Aluwong, T., Hassan, F., Dzenda, T., Kawu, M., & Ayo, J. (2013). Effect of different levels of supplemental yeast on body weight, thyroid hormone metabolism and lipid profile of broiler chick ens. Journal of Veterinary Medical Science, 75(3), 291-298.
Cui Ma, C., Gao, Q., Zhang, W., Zhu, Q., Tang, W., Blachier, F., & Kong, X. (2020). Supplementing Synbiotic in Sows’ Diets Modifies Beneficially Blood Parameters and Colonic Micro biota Composition and Metabolic Activity in Suckling Piglets. Frontiers in veterinary science, 7, 1004.
Dowarah, R., Verma, A. K., Agarwal, N., & Singh, P. (2018). Ef fect of swine-origin probiotic Pediococcus acidilactici FT28 on maintenance of antioxidant status, blood haematology and biochemical profile in early weaned grower-finisher pigs. Indi an Journal of Animal Sciences, 88(7), 779-785.
Eicher, S. D., McKee, C. A., Carroll, J. A., & Pajor, E. A. (2006). Supplemental vitamin C and yeast cell wall β-glucan as growth enhancers in newborn pigs and as immunomodulators after an endotoxin challenge after weaning. Journal of animal sci
ence, 84(9), 2352-2360.
Fuller. (1989). R, Probiotics in man and animal, Journal of Applied Bacteriology, 66p. 365-378.
Gang Liu, Yu, L., Martínez, Y., Ren, W., Ni, H., Abdullah Al-Dha bi, N., & Yin, Y. (2017). Dietary Saccharomyces cerevisiae cell wall extract supplementation alleviates oxidative stress and modulates serum amino acids profiles in weaned piglets. Oxi dative Medicine and Cellular Longevity, 2017, 3967-439.
Garasto, S., Montesanto, A., Corsonello, A., Lattanzio, F., Fusco, S., Passarino, G., & Corica, F. (2017). Thyroid hormones in ex treme longevity. Mechanisms of ageing and development, 165, 98-106.
Ko, H.Y. Yang, & I.S. Jang, (2004). Effect of conjugated linoleic acid on intestinal and hepatic antioxidant enzyme activity and lipid peroxidation in broiler chickens. Asian-Australian Journal of 18
Reddy et al DIETARY PREBIOTICS IN AUGMENTING THE ANTIOXIDANT...........
Animal Science, 17:1162-1167.
Li, W.F., Qin, H., Li, Y.L., Rajput, I.R., Yi, H., & Hu, C.H. (1986). Induction of probiotic strain Enterococcus faecium ef1 on the production of cytokines, superoxide anion and prostaglan din e2 in a macrophage cell line. Pakistan Veterinary. Journal, 32:530-534.
Li Gong, Wang, B., Mei, X., Xu, H., Qin, Y., Li, W., & Zhou, Y. (2018). Effects of three probiotic Bacillus on growth perfor mance, digestive enzyme activities, antioxidative capacity, se rum immunity, and biochemical parameters in broilers. Ani mal Science Journal, 89(11), 1561-1571.
Lutnicki, K., Szpringer, E. & Marcinak, A., (2006). Ethanol evoked oxidation- antioxidation imbalance in rats. Medicine Veteri nary. 62(6), 683-685.
Mancini, A., Di Segni, C., Raimondo, S., Olivieri, G., Silvestrini, A., Meucci, E., & Currò, D. (2016). Thyroid hormones, oxi dative stress, and inflammation. Mediators of inflammation, 2016, 6757-154.
O’Loughlin A, McGee M, Waters SM, Doyle S, & Earley B. (2011). Examination of the bovine leukocyte environment using im munogenetic biomarkers to assess immunocompetence fol lowing exposure to weaning stress. BMC Veterinary Research 7, 45–57.
Quigley, J. D. (2005). Mannan-oligosaccharides and other non-an tibiotic alternatives to the management of enteric disease of cattle. In American Association of Bovine Practitioners Pro ceedings of the Annual Conference, 19-24.
Runqi Fu, Chen, D., Tian, G., Zheng, P., Mao, X., Yu, J., & Yu, B. (2019). Effect of dietary supplementation of Bacillus coagu lans or yeast hydrolysates on growth performance, antioxidant activity, cytokines and intestinal microflora of growing- fin ishing pigs. Animal Nutrition, 5(4), 366-372.
Salehi-Abargouei, A., Ghiasvand, R., & Hariri, M. (2017). Prebiot
ics, prosynbiotics and synbiotics: can they reduce plasma oxi dative stress parameters? A systematic review. Probiotics and antimicrobial proteins, 9(1), 1-11.
Snedecor, G. W., & Cochran, W. G. (1994). Statistical methods. 8th edition East West Press Pvt. Ltd., New Delhi, India, 313. SPSS Inc., (2013). SPSS for windows (Release 22.0) Standard Ver sion. SPSS Inc. Headquarters, 233 S. Wacker Drive, 11th floor Chicago, Illinois 60606, USA.
Van der Aar, P. J., Molist, F. V., & Van Der Klis, J. D. (2017). The central role of intestinal health on the effect of feed additives on feed intake in swine and poultry. Animal feed science and technology, 233, 64-75.
Wang, W., Yang, H., Wang, Z., Han, J., Zhang, D., Sun, H., & Zhang, F. (2015). Effects of prebiotic supplementation on growth per formance, slaughter performance, growth of internal organs and small intestine and serum biochemical parameters of broilers. Journal of Applied Animal Research, 43(1), 33-38.
Wang, A. N., Yi, X. W., Yu, H. F., Dong, B., & Qiao, S. Y. (2009). Free radical scavenging activity of Lactobacillus fermentum in vitro and its antioxidative effect on growing–finishing pigs. Journal of Applied Microbiology, 107(4), 1140-1148.
Wu, C., & Wang, J. (2011). Effects of lactic acid bacteria and man nan oligosaccharides on growth performance and se rum biochemical parameters of weaned piglets. Jiangsu Journal of Agricultural Sciences, 27(1), 94-99.
Yaaru, L.P., R.S. Setiivari, N.K.S. Gowda, E. Antoniou, D.R. Ledoux & G.E. Rottinghaus, (2009). Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant and immune systems in broil er chicks fed aflatoxin. Poultry Sciences., 88: 2620-2627.
Yang, RL. W. Li, Y.H. Shi, & G.W. Le. (2008). Lipoic acid prevents high-fat diet- induced dyslipidemia and oxidative stress: a microarray analysis Nutrition, 24: 582-588.

