Evaluating Therapeutic Efficacy of Cephalexin and PGF2α in the Management of Endometritis in Crossbred Cattle
DOI:
https://doi.org/10.48165/ijvsbt.21.5.22Keywords:
Cephalexin, Crossbred cattle, Endometritis, PGF2αAbstract
Twenty-four cows diagnosed with subclinical endometritis (SCE) were divided into four equal groups: Group I (Cephalexin intrauterine infusion), Group II (intramuscular PGF2α), Group III (combined Cephalexin and PGF2α), and Group IV (untreated control). Diagnostic parameters included were haemato-biochemical, enzymatic, ultrasonographic and cytological assessments before treatment and after treatment (i.e. next estrus). White side test (WST) with a 45.83% positivity rate and endometrial cytology with PMN cell count exceeding 5% was found. PMN cell count decreased significantly, with Group III from 13.33 ± 0.67% to 2.50 ± 0.55% post-treatment. Ultrasonography indicated reductions in intraluminal fluid and endometrial thickness in treated groups. Post-treatment haemoglobin and TLC levels were highest in Group III with values of 11.42±0.19 g/dL and 10.15±0.10 × 10³/µL, respectively. Biochemical analyses showed significant increase in total protein and globulin levels in treated groups. Enzymatic activity of ALT and AST decreased significantly in Groups I and III, reflecting reduced uterine inflammation. Progesterone levels remained stable across all groups indicating normal luteal function. The findings highlight the efficacy of the combined Cephalexin and PGF2α treatment protocol (Group III) in normalizing altered haemato biochemical profile and managing SCE in bovine.
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