Immunomodulatory and Therapeutic Profile of Tinospora Cordifolia Linn. (Guduchi): A Phytopharmacological Review
Keywords:
Ayurveda, Guduchi, Immunomodulatory, Tinospora cordifolia Linn.Abstract
With the prime motive of preventing, promoting health and curing, treating diseases, Ayurveda has been into preaching and practicing for ages. With the holistic approach of managing diseases, Ayurveda has its established way of dealing a Vyadhi, with nature-based medical products. Guduchi, Tinospora cordifolia Linn. Being such a medicinal herb has been in Ayurvedic clinical use for its immense potential to heal and promote health. Ayurveda classics as well as modern day researches have shown a wide spectrum of utility of Guduchi. Guduchi has been termed to be anti-hyperglycaemic, anti oxidant, hepatoprotective, cardiovascular-protective, anti-allergic, anti-anxiety and stress, immunomodulatory, and many more. Since, Guduchi has a significant role in health preservation and treatment of diseases, this phytopharmacological review explores the immunomodulatory and therapeutic profile of Tinospora Cordifolia Linn. (Guduchi).
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1. Phan VK, Chau VM, Nguyen TD, La VK, Dan TH, Nguyen HN, Nguyen XC, Hoang TH, Trinh VL. Aporphine alkaloids, clerodane diterpenes, and other constituents from Tinospora cordifolia. Fitoterapia. 2010;81(6):485-9.
2. Mahima, Rahal A, Prakash A, Verma AK, Kumar V, Roy D. Proximate and elemental analyses of Tinospora cordifolia stem. Pak J Biol Sci. 2014;17(5):744-7.
3. Khan MI, Harsha PS, Giridhar P, Ravishankar GA. Pigment identification, antioxidant activity, and nutrient composition of Tinospora cordifolia (willd.) Miers ex Hook. f & Thoms fruit. Int J Food Sci Nutr. 2011;62(3):239-49.
4. Saha S, Ghosh S. Tinospora cordifolia: One plant, many roles. Anc Sci Life. 2012;31(4):151-9. doi: 10.4103/0257-7941.107344 5. Ayurveda Pharmacopeia of India. Available from: https://www. ayurveda.hu/api/api/vol/1.pdf [Last accessed on 2021 Dec 15]. 6. Acharya YT. Charaka samhita. Varanasi: Chaukhambha Orientalia; 2011.
7. Acharya YT. Sushruta samhita. 7th ed. Varanasi: Chaukhambha Orientalia; 2012.
8. Paradakara HS. Ashtanga hridaya. Varanasi: Chaukhambha Surabharati Prakashana; 2010.
9. Upadhaya AK, Kumar K, Kumar A, Mishra HS. Tinospora cordifolia (Willd.) Hook. F. and Thoms. (Guduchi) - validation of the ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res. 2010;1:112-21.
10. Rout GR. Identification of Tinospora cordifolia (Willd.) Miers ex hook F & Thoms using RAPD markers. Z Naturforsch C J Biosci. 2006;61:118-22.
11. Sriramaneni RN, Omar AZ, Ibrahim SM, Amirin S, Zaini AM. Vasorelaxant effect of diterpenoid lactones from Andrographis paniculata chloroform extract on rat aortic rings. Pharmacognosy Res. 2010;2:242-6.
12. Ly PT, Singh S, Shaw CA. Novel environmental toxins: Steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases. J Neurosci Res. 2007;85:231-7.
13. Lv J, Xu D, Perkovic V, Ma X, Johnson DW, Woodward M, Levin A, Zhang H, Wang H, TESTING Study Group. Corticosteroid therapy in IgA nephropathy. J Am Soc Nephrol. 2012;23:1108-16.
14. Wang T, Liu YY, Wang X, Yang N, Zhu HB, Zuo PP. Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGP and NGF signalling. Acta Pharmacol Sin. 2010;31:765-74.
15. Sharma U, Bala M, Saini R, Verma PK, Kumar N, Singh B, MunshiRK, Bhalerao S. Polysaccharide enriched immunomodulatory fractions from Tinospora cordifolia (Willd) miers ax hook. F. & Thoms. Indian J Exp Biol. 2012;50(9):612-7.
16. Sudhakaran DS, Srirekha P, Devasree LD, Premsingh S, Michael RD. Immunostimulatory effect of Tinospora cordifolia Miers leaf extract in Oreochromis mossambicus. Indian J Exp Biol. 2006;44(9):726-32.
17. Rohatgi S. Ayurvedic Composition for the Prophylaxis and Treatment of AIDS, flu, TB and other Immuno-Deficiencies and the Process for Preparing the Same. Patents No. US5529778; 1996.
18. Pushpangadan P, Rao CV, Rawat AK, Ojha SK, Reddy GD. Anti Allergic Herbal Formulation. Patents No. US7344739; 2008. 19. More P, Pai K. In vitro NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of macrophages after Tinospora cordifolia (guduchi) treatment. Immunopharmacol Immunotoxicol. 2012;34(3):368-72.
20. Sangeetha MK, Balaji Raghavendran HR, Gayathri V, Vasanthi HR. Tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats. J Nat Med. 2011;65(3-4):544-50.
21. Sudha P, Zinjarde SS, Bhargava SY, Kumar AR. Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants. BMC Complement Altern Med. 2011;11:5.
22. Goel B, Pathak N, Nim DK, Singh SK, Dixit RK, Chaurasia R. Clinical evaluation of analgesic activity of guduchi (Tinospora cordifolia) using animal model. J Clin Diagn Res. 2014;8(8):HC01-4.
23. Sannegowda KM, Venkatesha SH, Moudgil KD. Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage. Int J Immunopathol Pharmacol. 2015;28(4):521-31.
24. Cicero AF, Baggioni A. Berberine and its role in chronic disease. Adv Exp Med Biol. 2016;928:27-45.
25. Kumari S, Mittal A, Dabur R. Moderate alcohol consumption in chronic form enhances the synthesis of cholesterol and C-21 steroid hormones, while treatment with Tinospora cordifolia modulate these events in men. Steroids. 2016;114:68-77.
26. Kumar V, Modi PK, Saxena KK. Exploration of hepatoprotective activity of aqueous extract of Tinospora cordifolia-an experimental study. Asian J Pharm Clin Res. 2013;6(1):87-91.
27. Subramanian M, Chintalwar GJ, Chattopadhyay S. Antioxidant properties of a Tinospora cordifolia polysaccharide against iron mediated lipid damage and x-ray induced protein damage. Redox Rep. 2013;7(3):137-43.
28. Sarala M, Velu V, Anandharamakrishnan C, Singh RP. Spray drying of Tinospora cordifolia leaf and stem extract and evaluation of antioxidant activity. J Food Sci Technol. 2012;49(1):119-22.
29. Gupta R, Sharma V. Ameliorative effects of Tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-b(1) in mice kidney. Toxicol Int. 2011;18(2):94-8.
30. Narayanan AS, Raja SS, Ponmurugan K, Kandekar SC, Natarajaseenivasan K, Maripandi A, Mandeel QA. Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: A study from Kolli Hills, Tamil Nadu, India. Benef Microbes. 2011;2(3):235-43.
31. Sharma V, Pandey D. Beneficial effects of Tinospora cordifolia on blood profiles in male mice exposed to lead. Toxicol Int. 2010;17(1):8-11.
32. Kulkarni R, Shetty SK, Rajarajeshwari NM, Rao PN, Nayan J. Rasayana herbs of ayurveda to treat age related cognitive decline: An update. Pharmacogn J. 2016;8(5):411-23.
33. Dhingra D, Goyal PK. Evidences for the involvement of monoaminergic and gabaergic systems in antidepressant-like activity of Tinospora cordifolia in mice. Indian J Pharm Sci. 2008;70(6):761-7.
34. Dhama K, Sachan S, Khandia R, Munjal A, Iqbal H, Latheef SK, Karthik K, Samad HA, Tiwari R, Dadar M. Medicinal and beneficial health applications of Tinospora cordifolia (Guduchi): A miraculous herb countering various diseases/disorders and its immunomodulatory effects. Recent Pat Endocr Metab Immune Drug Discov 2017;10(2):96-
111. doi: 10.2174/1872214811666170301105101
35. Parthipan M, Aravindhan V, Rajendran A. Medico-botanical study of Yercaud hills in the Eastern Ghats of Tamil Nadu, India. Anc Sci Life. 2011;30(4):104-9.
