Ultrasonographic and Dopplerfluxometria Assessment of Renal Function in Pyometra-Affected Bitches
DOI:
https://doi.org/10.48165/ijar.2025.46.03.12Keywords:
Pyometra, Renal impairment, Doppler ultrasonography, UPCRAbstract
Pyometra is a complex diestrual disorder that primarily affects the uterus in mature bitches and can have systemic effects on various organs and physiological systems. One of the main complications observed with this disease is its renal affection. Though detection of renal impairment has been traditionally done by evaluating serum biochemical values or urinary biochemical results; analysis of renal size and perfusion employing ultrasonography and Dopplerfluxometria offer new means of analysis. The aim of this study was to evaluate the renal function in pyometra affected bitches employing the traditionally used serum and urinary parameters as well as ultrasonographic and Dopplerfluxometria assessment. Thirteen bitches affected with pyometra and six healthy bitches, kept as control, were used in the study. The animals were assessed for renal injury by evaluating serological parameters such as blood urea nitrogen (BUN) and creatinine; urinary protein to creatinine ratio (UPCR) and renal ultrasonographic evaluation and Dopplerfluxometria. It was noted that Dopplerfluxometria of renal artery offered evidence of renal damage in instances where serological, urinary and renal size assessments failed to detect any indications of renal impairment in pyometra affected bitches.
References
Batista, P. R., Gobello, C., Rube, A., Corrada, Y. A., Tortora, M., & Blanco, P. G. (2016). Uterine blood flow evaluation in bitches suffering from cystic endometrial hyperplasia (CEH) and CEH-pyometra complex. Theriogenology, 85, 1258–1261.
de Andrade, M. G. M. G., Leme, F. O. P., Paes, P. R. O., & Gheller, V. A. (2014). Avaliação da gama-glutamiltransferase na urina de cadelas com piometra. Vet. News, 20, 1–7.
De Loor, J., Daminet, S., Smets, P., Maddens, B., & Meyer, E. (2013). Urinary biomarkers for acute kidney injury in dogs. J. Vet. Intern. Med., 27(5), 998–1010.
Figueiredo, M. S., Malm, C., Mamão, L. D., Oliveira, J., Veado, J. C. C., Costa, M. P., Valente, P. C. L. G., Horta, R. S., Castro, M. L., Castro, A. G., Sbaraini, L., & Souza, E. M. (2017). Renal injury in dogs with pyometra. Cienc. Rural, 47(5), 1–7.
Gasser, B., Uscategui, R. A. R., Maronezi, M. C., Pavan, L., Simões, A. P. R., Martinato, F., Silva, P., Crivellenti, L. Z., & Feliciano, M. A. R. (2020). Clinical and ultrasound variables for early diagnosis of septic acute kidney injury in bitches with pyometra. Sci. Rep., 10, 8994.
Hagman, R. (2014). Diagnostic and prognostic markers for uterine diseases in dogs. Reprod. Domest. Anim., 49, 16–20.
Heiene, R., Kristiansen, V., Teige, J., & Jansen, J. H. (2007). Renal histomorphology in dogs with pyometra and control dogs, and long-term clinical outcome with respect to signs of kidney disease. Acta Vet. Scand., 49(1), 1–9.
Heiene, R., Moe, L., & Mølmen, G. (2001). Calculation of urinary enzyme excretion, with renal structure and function in dogs with pyometra. Res. Vet. Sci., 70(2), 129–137.
Jitpean, S., Ambrosen, A., Emanuelson, U., & Hagman, R. (2017). Closed cervix is associated with more severe illness in dogs with pyometra. BMC Vet. Res., 13, 1–7.
Kalantarinia, K. (2009). Novel imaging techniques in acute kidney injury. Curr. Drug Targets, 10, 1184–1189.
Koenhemsi, L., Toydemir, S., Ucmak, M., Gonul, R., & Or, M. E. (2016). Evaluation of early renal disease in bitches with pyometra based on renal doppler measurements. Vet. Med. (Czech), 61, 344–347.
Kustritz, M. V. R. (2006). Collection of tissue and culture samples from the canine reproductive tract. Theriogenology, 66, 567–574.
Maddens, B., Heiene, R., Smets, P., Svensson, M., Aresu, L., Van der Lugt, J., Daminet, S., & Meyer, E. (2011). Evaluation of kidney injury in dogs with pyometra based on proteinuria, renal histomorphology, and urinary biomarkers. J. Vet. Intern. Med., 25(5), 1075–1083.
Marangon, W. F., Assis, M. M. Q., de Paula Xavier, N. S., & de Gaspari, R. (2017). Piometra com insuficiência renal aguda em cadela – relato de caso. Revista Campo Digital, 12(1), 14–20.
Mareschal, A., D’Anjou, M. A., Moreau, M., Alexander, K., & Beauregard, G. (2007). Ultrasonographic measurement of kidney‐to‐aorta ratio as a method of estimating renal size in dogs. Vet. Radiol. Ultrasound, 48(5), 434–438.
Morrow, K. L., Salman, M. D., Lappin, M. R., & Wrigley, R. (1996). Comparison of the resistive index to clinical parameters in dogs with renal disease. Vet. Radiol. Ultrasound, 37(3), 193–199.
Rimer, D., Chen, H., Bar-Nathan, M., & Segev, G. (2022). Acute kidney injury in dogs: etiology, clinical and clinicopathologic findings, prognostic markers, and outcome. J. Vet. Intern. Med., 36(2), 609–618.
Sant’Anna, M. C., Giordano, L. G. P., Flaiban, K. K. M. C., Muller, E. E., & Martins, M. I. M. (2014). Prognostic markers of canine pyometra. Arq. Bras. Med. Vet. Zootec., 66(6), 1711–1717.
Santos, F. D. N., Watanabe, M., Vasco, C. F., Fonseca, C. D. D., & Vattimo, M. D. F. F. (2014). Antioxidant protection of statins in acute kidney injury induced by sepsis. Rev. Esc. Enferm. USP, 48(5), 820–826.
Slot, C. (1965). Plasma creatinine determination; A new and specific Jaffe reaction method. Scand. J. Clin. Lab., 17, 381–387.
Taylor, A. J., & Vadgama, P. (1992). Analytical reviews in clinical biochemistry: the estimation of urea. Ann. Clin. Biochem., 19, 245–264.
